Abstract
Recent studies suggested that microRNA-200 family microRNAs play critical roles in cancer initiation and metastasis. The underlying mechanism remained elusive. In this study, we show that microRNA-200c is upregulated in nasopharyngeal carcinoma cells. Manipulation of microRNA-200c levels affected cell growth, migration, and invasion in nasopharyngeal carcinoma cell lines. Furthermore, PTEN was identified as a direct target of microRNA-200c. Overexpression of PTEN resulted in similar effects to those of anti-microRNA-200c transfection. In vivo suppression of microRNA-200c level reduced tumor growth in mice. Overall, our data suggest that microRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN.
| Original language | English |
|---|---|
| Journal | Tumor Biology |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2017 |
Bibliographical note
Publisher Copyright:© The Author(s) 2017.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Growth
- Invasion
- MicroRNA-200c
- Migration
- Nasopharyngeal carcinoma
- PTEN
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