Abstract
Mitotic catastrophe is generally defined as a mode of cell death or irreversible growth arrest associated with aberrant mitotic activity. It is characterized by an unscheduled activation of cyclin B1-CDK1. Conditions that can trigger mitotic catastrophe include precocious entry into mitosis and prolonged mitotic block. Mitotic catastrophe induces cell death during mitosis or following abnormal mitotic exit such as mitotic slippage. Failure of cells to undergo mitotic catastrophe is believed to contribute to genome instability and tumorigenesis. Furthermore, many anticancer strategies involve inducing cancer cells to undergo mitotic catastrophe.
| Original language | English |
|---|---|
| Title of host publication | Functional Cell Biology |
| Publisher | Elsevier Inc. |
| Pages | 399-403 |
| Number of pages | 5 |
| Volume | 3 |
| ISBN (Electronic) | 9780123944474 |
| ISBN (Print) | 9780123947963 |
| DOIs | |
| Publication status | Published - 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anticancer therapies
- Apoptosis
- Cancer
- Cell death
- Cyclin
- Cyclin-dependent kinase
- DNA damage
- Genome instability
- Mitosis
- Mitotic slippage
- Necrosis
- Spindle-assembly checkpoint
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