@inproceedings{ccca1a89c8074181aae39f155a91c073,
title = "Multi-resolution LC-MS images alignment using dynamic time warping and Kullback-Leibler distance",
abstract = "Liquid chromatography mass spectrometry (LC-MS) is widely used in comparing proteomes for disease biomarker discovery. An LC-MS experiment produces a 2-D image, where the mass-to-charge ratio and the chromatographic retention time are the coordinates, and the signal intensities represent the abundance of detected peptides. However, there is always a non-linear retention time difference across replicate LC-MS images due to machine drift, such that synchronization of LC-MS images must be performed prior to any further analysis. In this paper, we propose a multi-resolution image alignment scheme to synchronize LC-MS images. Dynamic Time Warping (DTW) is used to reconcile the time differences among images and Kullback-Leibler distance (KLD) is used as a local distance measure. Our proposed scheme has been validated using two real data sets, and promising results have been obtained.",
keywords = "DTW, KLD, LC-MS, multi-resolution",
author = "Wu, \{William K.H.\} and Chung, \{Albert C.S.\} and Lam, \{Henry H.N.\}",
year = "2012",
doi = "10.1109/ICIP.2012.6467201",
language = "English",
isbn = "9781467325332",
series = "Proceedings - International Conference on Image Processing, ICIP",
pages = "1681--1684",
booktitle = "2012 IEEE International Conference on Image Processing, ICIP 2012 - Proceedings",
note = "2012 19th IEEE International Conference on Image Processing, ICIP 2012 ; Conference date: 30-09-2012 Through 03-10-2012",
}