Optimisation of animal cell culture media using dynamic simulation

C. S. Sanderson; G. W. Barton; J. P. Barford

doi:10.1016/0098-1354(95)87114-4

Optimisation of animal cell culture media using dynamic simulation

C. S. Sanderson^*, G. W. Barton, J. P. Barford

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Citations (Scopus)

Abstract

A dynamic model for the growth of animal cells in culture is used in combination with an optimisation algorithm to design a medium for improved cell growth. By manipulating the initial concentrations of glucose and glutamine, the model predicts that the profitability of a murine hybridoma culture can be doubled compared to a culture grown on a standard medium. The model indicates that further improvements are achievable and allows interesting metabolic features to be observed and explained.

Original language	English
Pages (from-to)	681-686
Number of pages	6
Journal	Computers and Chemical Engineering
Volume	19
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0098-1354(95)87114-4
Publication status	Published - 1995
Externally published	Yes

Keywords

Animal cell culture
SpeedUp.
dynamic simulation
media design
optimisation

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10.1016/0098-1354(95)87114-4

Cite this

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title = "Optimisation of animal cell culture media using dynamic simulation",

abstract = "A dynamic model for the growth of animal cells in culture is used in combination with an optimisation algorithm to design a medium for improved cell growth. By manipulating the initial concentrations of glucose and glutamine, the model predicts that the profitability of a murine hybridoma culture can be doubled compared to a culture grown on a standard medium. The model indicates that further improvements are achievable and allows interesting metabolic features to be observed and explained.",

keywords = "Animal cell culture, SpeedUp., dynamic simulation, media design, optimisation",

author = "Sanderson, \{C. S.\} and Barton, \{G. W.\} and Barford, \{J. P.\}",

year = "1995",

doi = "10.1016/0098-1354(95)87114-4",

language = "English",

volume = "19",

pages = "681--686",

journal = "Computers and Chemical Engineering",

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T1 - Optimisation of animal cell culture media using dynamic simulation

AU - Sanderson, C. S.

AU - Barton, G. W.

AU - Barford, J. P.

PY - 1995

Y1 - 1995

N2 - A dynamic model for the growth of animal cells in culture is used in combination with an optimisation algorithm to design a medium for improved cell growth. By manipulating the initial concentrations of glucose and glutamine, the model predicts that the profitability of a murine hybridoma culture can be doubled compared to a culture grown on a standard medium. The model indicates that further improvements are achievable and allows interesting metabolic features to be observed and explained.

AB - A dynamic model for the growth of animal cells in culture is used in combination with an optimisation algorithm to design a medium for improved cell growth. By manipulating the initial concentrations of glucose and glutamine, the model predicts that the profitability of a murine hybridoma culture can be doubled compared to a culture grown on a standard medium. The model indicates that further improvements are achievable and allows interesting metabolic features to be observed and explained.

KW - Animal cell culture

KW - SpeedUp.

KW - dynamic simulation

KW - media design

KW - optimisation

UR - https://openalex.org/W2067711082

UR - https://www.scopus.com/pages/publications/0029231462

U2 - 10.1016/0098-1354(95)87114-4

DO - 10.1016/0098-1354(95)87114-4

M3 - Journal Article

SN - 0098-1354

VL - 19

SP - 681

EP - 686

JO - Computers and Chemical Engineering

JF - Computers and Chemical Engineering

IS - SUPPL. 1

ER -

Optimisation of animal cell culture media using dynamic simulation

Abstract

Keywords

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