Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

J. Tze Fei Wong

doi:10.1007/BF01809445

Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

J. Tze Fei Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

59 Citations (Scopus)

Abstract

The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.

Original language	English
Pages (from-to)	165-176
Number of pages	12
Journal	Origins of life and evolution of the biosphere
Volume	21
Issue number	3
DOIs	https://doi.org/10.1007/BF01809445
Publication status	Published - May 1991

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abstract = "The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.",

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AB - The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.

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Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

Abstract

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