Peripheral Hyperinsulinemia Confers Neuronal Insulin Resistance and Dysfunction in Alzheimer's Disease

The risk of developing Alzheimer’s disease (AD) is almost double in patients with insulin resistance. Prolong hyperinsulinemia is a major cause of insulin resistance. At early stage when brain insulin import remains intact, brain insulin level would become chronically saturated and yet direct effects of such on neurons remain elusive. Determining whether these peripheral abnormalities initiate AD-related changes including amyloid, tangles and synaptic loss is important for understanding AD and development of effective therapeutics strategies.