Protective effect of a new amide compound from pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide

Liang Zhang; Zhi Zhong Ma; Yan Yun Che; Ning Li; Peng Fei Tu

doi:10.1016/j.fitote.2010.10.009

Protective effect of a new amide compound from pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide

Liang Zhang, Zhi Zhong Ma, Yan Yun Che, Ning Li, Peng Fei Tu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

26 Citations (Scopus)

Abstract

A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H₂O₂ was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H₂O₂- induced cell death of HMEC.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Fitoterapia
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.fitote.2010.10.009
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

3,4-Dihydroxybenzoic acid
Amide
Camellia assamica (Mast.) Chang
Human micro-vascular endothelial cell

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10.1016/j.fitote.2010.10.009

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title = "Protective effect of a new amide compound from pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide",

abstract = "A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H2O2 was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H2O2- induced cell death of HMEC.",

keywords = "3,4-Dihydroxybenzoic acid, Amide, Camellia assamica (Mast.) Chang, Human micro-vascular endothelial cell",

author = "Liang Zhang and Ma, \{Zhi Zhong\} and Che, \{Yan Yun\} and Ning Li and Tu, \{Peng Fei\}",

year = "2011",

month = mar,

doi = "10.1016/j.fitote.2010.10.009",

language = "English",

volume = "82",

pages = "267--271",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Protective effect of a new amide compound from pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide

AU - Zhang, Liang

AU - Ma, Zhi Zhong

AU - Che, Yan Yun

AU - Li, Ning

AU - Tu, Peng Fei

PY - 2011/3

Y1 - 2011/3

N2 - A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H2O2 was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H2O2- induced cell death of HMEC.

AB - A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H2O2 was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H2O2- induced cell death of HMEC.

KW - 3,4-Dihydroxybenzoic acid

KW - Amide

KW - Camellia assamica (Mast.) Chang

KW - Human micro-vascular endothelial cell

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000287567800025

U2 - 10.1016/j.fitote.2010.10.009

DO - 10.1016/j.fitote.2010.10.009

M3 - Journal Article

SN - 0367-326X

VL - 82

SP - 267

EP - 271

JO - Fitoterapia

JF - Fitoterapia

IS - 2

ER -

Protective effect of a new amide compound from pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide

Abstract

Keywords

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