Abstract
Background: Merlin controls organ size by binding to target proteins both in cytoplasm and nucleus. Results: The structure of Merlin FERM domain in complex with its binding domain of DCAF1 is determined. Conclusion: DCAF1 folds into a β -hairpin structure and binds to the F3 lobe of Merlin FERM domain. Significance: The structure of the Merlin · DCAF1 complex provides a template for understanding the interactions of Merlin with its binding partners.
| Original language | English |
|---|---|
| Pages (from-to) | 14674-14681 |
| Number of pages | 8 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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