TY - JOUR
T1 - Studies on the [4 + 2] cycloaddition and allylic substitution of indole-fused zwitterionic π-allylpalladium
AU - Han, Zhengyu
AU - Xue, Yu
AU - Li, Xiang
AU - Hu, Xinzhe
AU - Dong, Xiu Qin
AU - Sun, Jianwei
AU - Huang, Hai
N1 - Publisher Copyright:
© 2023 The Royal Society of Chemistry
PY - 2023/9/25
Y1 - 2023/9/25
N2 - The zwitterionic π-allylpalladium species, also known as dipoles, are important synthons widely used in various reactions including cycloaddition and allylic substitution. This study reported the development of a new indole-fused zwitterionic π-allylpalladium precursor compound and its application in [4 + 2] cycloaddition and allylic substitution reactions. As a result, the synthesis of pyrrolo[3,2,1-ij]quinazolin-3-one and 7-vinyl indole compounds was achieved with moderate to good yields. Notably, the allylic substitution reaction exhibited excellent regio- and stereoselectivity.
AB - The zwitterionic π-allylpalladium species, also known as dipoles, are important synthons widely used in various reactions including cycloaddition and allylic substitution. This study reported the development of a new indole-fused zwitterionic π-allylpalladium precursor compound and its application in [4 + 2] cycloaddition and allylic substitution reactions. As a result, the synthesis of pyrrolo[3,2,1-ij]quinazolin-3-one and 7-vinyl indole compounds was achieved with moderate to good yields. Notably, the allylic substitution reaction exhibited excellent regio- and stereoselectivity.
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001074348000001
UR - https://openalex.org/W4387016773
UR - https://www.scopus.com/pages/publications/85174748320
U2 - 10.1039/d3ob01451g
DO - 10.1039/d3ob01451g
M3 - Journal Article
C2 - 37782136
SN - 1477-0520
VL - 21
SP - 8162
EP - 8169
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 40
ER -