Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands

Xiang Li Wang; Hui Chao; Hong Li; Xian Lan Hong; Liang Nian Ji; Xiao Yuan Li

doi:10.1016/j.jinorgbio.2003.12.006

Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands

Xiang Li Wang
, Hui Chao^*
, Hong Li
, Xian Lan Hong
, Liang Nian Ji
, Xiao Yuan Li

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal Article › peer-review

108 Citations (Scopus)

Abstract

Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl ₂]·0.25H₂O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl₂] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl₂]<[Cu(pta) Cl₂]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl₂] exhibited the higher cleaving efficiency.

Original language	English
Pages (from-to)	423-429
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	98
Issue number	3
DOIs	https://doi.org/10.1016/j.jinorgbio.2003.12.006
Publication status	Published - Mar 2004

Keywords

Asymmetric tridentate ligand
Copper(II) complex
DNA cleavage

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10.1016/j.jinorgbio.2003.12.006

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title = "Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands",

abstract = "Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl 2]·0.25H2O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl2] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl2]<[Cu(pta) Cl2]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl2] exhibited the higher cleaving efficiency.",

keywords = "Asymmetric tridentate ligand, Copper(II) complex, DNA cleavage",

author = "Wang, \{Xiang Li\} and Hui Chao and Hong Li and Hong, \{Xian Lan\} and Ji, \{Liang Nian\} and Li, \{Xiao Yuan\}",

year = "2004",

month = mar,

doi = "10.1016/j.jinorgbio.2003.12.006",

language = "English",

volume = "98",

pages = "423--429",

journal = "Journal of Inorganic Biochemistry",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands

AU - Wang, Xiang Li

AU - Chao, Hui

AU - Li, Hong

AU - Hong, Xian Lan

AU - Ji, Liang Nian

AU - Li, Xiao Yuan

PY - 2004/3

Y1 - 2004/3

N2 - Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl 2]·0.25H2O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl2] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl2]<[Cu(pta) Cl2]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl2] exhibited the higher cleaving efficiency.

AB - Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl 2]·0.25H2O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl2] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl2]<[Cu(pta) Cl2]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl2] exhibited the higher cleaving efficiency.

KW - Asymmetric tridentate ligand

KW - Copper(II) complex

KW - DNA cleavage

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000220269300001

UR - https://openalex.org/W1967956764

U2 - 10.1016/j.jinorgbio.2003.12.006

DO - 10.1016/j.jinorgbio.2003.12.006

M3 - Journal Article

SN - 0162-0134

VL - 98

SP - 423

EP - 429

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 3

ER -

Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands

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Keywords

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