TY - JOUR
T1 - Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands
AU - Wang, Xiang Li
AU - Chao, Hui
AU - Li, Hong
AU - Hong, Xian Lan
AU - Ji, Liang Nian
AU - Li, Xiao Yuan
PY - 2004/3
Y1 - 2004/3
N2 - Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl 2]·0.25H2O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl2] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl2]<[Cu(pta) Cl2]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl2] exhibited the higher cleaving efficiency.
AB - Two asymmetric tridentate copper(II) complexes, [Cu(dppt)Cl 2]·0.25H2O (1) (dppt=3-(1,10-phenanthrolin-2-yl)-5, 6-diphenyl-as-triazine) and [Cu(pta)Cl2] (2) (pta=3-(1,10- phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene), have been prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra. Complex 1 has also been structurally characterized. The complexes exist as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. DNA interaction studies suggest that the ligand planarity of the complex has a significant effect on DNA binding affinity increasing in the order [Cu(dppt)Cl2]<[Cu(pta) Cl2]. In the presence of ascorbate or glutathione, the two complexes are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl2] exhibited the higher cleaving efficiency.
KW - Asymmetric tridentate ligand
KW - Copper(II) complex
KW - DNA cleavage
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000220269300001
UR - https://openalex.org/W1967956764
UR - https://www.scopus.com/pages/publications/1342286725
U2 - 10.1016/j.jinorgbio.2003.12.006
DO - 10.1016/j.jinorgbio.2003.12.006
M3 - Journal Article
SN - 0162-0134
VL - 98
SP - 423
EP - 429
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 3
ER -