Trafficking regulation of proteins in Alzheimer's disease

Shangtong Jiang; Yanfang Li; Xian Zhang; Guojun Bu; Huaxi Xu; Yun Wu Zhang

doi:10.1186/1750-1326-9-6

Trafficking regulation of proteins in Alzheimer's disease

Shangtong Jiang, Yanfang Li, Xian Zhang, Guojun Bu, Huaxi Xu, Yun Wu Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

127 Citations (Scopus)

Abstract

The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

Original language	English
Article number	6
Journal	Molecular Neurodegeneration
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1750-1326-9-6
Publication status	Published - 11 Jan 2014
Externally published	Yes

Keywords

A Disintegrin and Metalloprotease 10
Alzheimer's disease
Amyloid beta (A4) precursor protein
Beta-site APP-cleaving enzyme 1
Trafficking
α-secretase
β-secretase
γ-secretase

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10.1186/1750-1326-9-6

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title = "Trafficking regulation of proteins in Alzheimer's disease",

abstract = "The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.",

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T1 - Trafficking regulation of proteins in Alzheimer's disease

AU - Jiang, Shangtong

AU - Li, Yanfang

AU - Zhang, Xian

AU - Bu, Guojun

AU - Xu, Huaxi

AU - Zhang, Yun Wu

PY - 2014/1/11

Y1 - 2014/1/11

N2 - The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

AB - The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

KW - A Disintegrin and Metalloprotease 10

KW - Alzheimer's disease

KW - Amyloid beta (A4) precursor protein

KW - Beta-site APP-cleaving enzyme 1

KW - Trafficking

KW - α-secretase

KW - β-secretase

KW - γ-secretase

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UR - https://openalex.org/W2138178640

UR - https://www.scopus.com/pages/publications/84892377524

U2 - 10.1186/1750-1326-9-6

DO - 10.1186/1750-1326-9-6

M3 - Review article

C2 - 24410826

SN - 1750-1326

VL - 9

JO - Molecular Neurodegeneration

JF - Molecular Neurodegeneration

IS - 1

M1 - 6

ER -

Trafficking regulation of proteins in Alzheimer's disease

Abstract

Keywords

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