Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

Bill Ling; Bilge Gungoren; Yuxing Yao; Przemysław Dutka; Reid Vassallo; Rohit Nayak; Cameron A.B. Smith; Justin Lee; Margaret B. Swift; Mikhail G. Shapiro

Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

Bill Ling, Bilge Gungoren, Yuxing Yao, Przemysław Dutka, Reid Vassallo, Rohit Nayak, Cameron A.B. Smith, Justin Lee, Margaret B. Swift, Mikhail G. Shapiro^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Citations (Scopus)

Abstract

Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.

Original language	English
Article number	2307106
Journal	Advanced Materials
Volume	36
Issue number	28
Publication status	Published - 11 Jul 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Advanced Materials published by Wiley-VCH GmbH.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cavitation
gas vesicles
molecular imaging
nanomedicine
ultrasound

Access to Document

https://hdl.handle.net/1783.1/146072

Cite this

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title = "Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy",

abstract = "Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.",

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language = "English",

volume = "36",

journal = "Advanced Materials",

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T1 - Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

AU - Ling, Bill

AU - Gungoren, Bilge

AU - Yao, Yuxing

AU - Dutka, Przemysław

AU - Vassallo, Reid

AU - Nayak, Rohit

AU - Smith, Cameron A.B.

AU - Lee, Justin

AU - Swift, Margaret B.

AU - Shapiro, Mikhail G.

PY - 2024/7/11

Y1 - 2024/7/11

N2 - Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.

AB - Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble-based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air-filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.

KW - cavitation

KW - gas vesicles

KW - molecular imaging

KW - nanomedicine

KW - ultrasound

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001185246900001

UR - https://openalex.org/W4392196681

UR - https://www.scopus.com/pages/publications/85187678717

M3 - Journal Article

SN - 0935-9648

VL - 36

JO - Advanced Materials

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ER -

Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy

Abstract

Bibliographical note

UN SDGs

Keywords

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