Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Kenward Vong; Karine Auclair

doi:10.1039/c2md00253a

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Kenward Vong, Karine Auclair^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however threatening to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6′-N-acetyltransferase (AAC(6′)).

Original language	English
Pages (from-to)	397-407
Number of pages	11
Journal	MedChemComm
Volume	3
Issue number	4
DOIs	https://doi.org/10.1039/c2md00253a
Publication status	Published - Apr 2012
Externally published	Yes

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abstract = "Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however threatening to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6′-N-acetyltransferase (AAC(6′)).",

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AB - Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however threatening to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6′-N-acetyltransferase (AAC(6′)).

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JO - MedChemComm

JF - MedChemComm

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ER -

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Abstract

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