TY - JOUR
T1 - UNIQUIMER 3D, a software system for structural DNA nanotechnology design, analysis and evaluation
AU - Zhu, Jinhao
AU - Wei, Bryan
AU - Yuan, Yuan
AU - Mi, Yongli
PY - 2009
Y1 - 2009
N2 - A user-friendly software system, UNIQUIMER 3D, was developed to design DNA structures for nanotechnology applications. It consists of 3D visualization, internal energy minimization, sequence generation and construction of motif array simulations (2D tiles and 3D lattices) functionalities. The system can be used to check structural deformation and design errors under scaled-up conditions. UNIQUIMER 3D has been tested on the design of both existing motifs (holiday junction, 4 × 4 tile, double crossover, DNA tetrahedron, DNA cube, etc.) and nonexisting motifs (soccer ball). The results demonstrated UNIQUIMER 3D's capability in designing large complex structures. We also designed a de novo sequence generation algorithm. UNIQUIMER 3D was developed for the Windows environment and is provided free of charge to the nonprofit research institutions.
AB - A user-friendly software system, UNIQUIMER 3D, was developed to design DNA structures for nanotechnology applications. It consists of 3D visualization, internal energy minimization, sequence generation and construction of motif array simulations (2D tiles and 3D lattices) functionalities. The system can be used to check structural deformation and design errors under scaled-up conditions. UNIQUIMER 3D has been tested on the design of both existing motifs (holiday junction, 4 × 4 tile, double crossover, DNA tetrahedron, DNA cube, etc.) and nonexisting motifs (soccer ball). The results demonstrated UNIQUIMER 3D's capability in designing large complex structures. We also designed a de novo sequence generation algorithm. UNIQUIMER 3D was developed for the Windows environment and is provided free of charge to the nonprofit research institutions.
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000265741600010
UR - https://openalex.org/W2161686873
UR - https://www.scopus.com/pages/publications/65549158772
U2 - 10.1093/nar/gkp005
DO - 10.1093/nar/gkp005
M3 - Journal Article
C2 - 19228709
SN - 0305-1048
VL - 37
SP - 2164
EP - 2175
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 7
ER -