Unpaired Optical Coherence Tomography Angiography Image Super-Resolution via Frequency-Aware Inverse-Consistency GAN

For optical coherence tomography angiography (OCTA) images, the limited scanning rate leads to a trade-off between field-of-view (FOV) and imaging resolution. Although larger FOV images may reveal more parafoveal vascular lesions, their application is hampered due to lower resolution. To increase the resolution, previous works only achieved satisfactory performance by using paired data for training, but real-world applications are limited by the challenge of collecting large-scale paired images. Thus, an unpaired approach is highly demanded. Generative Adversarial Network (GAN) has been commonly used in the unpaired setting, but it may struggle to accurately preserve fine-grained capillary details, which are critical biomarkers for OCTA. In this paper, our approach aspires to preserve these details by leveraging the frequency information, which represents details as high-frequencies (hf) and coarse-grained features as low-frequencies (lf). We propose a GAN-based unpaired super-resolution method for OCTA images and exceptionally emphasize hf fine capillaries through a dual-path generator. To facilitate a precise spectrum of the reconstructed image, we also propose a frequency-aware adversarial loss for the discriminator and introduce a frequency-aware focal consistency loss for end-to-end optimization. We collected a paired dataset for evaluation and showed that our method outperforms other state-of-the-art unpaired methods both quantitatively and visually.